Telix at ANZSNM Annual Scientific Meeting 2025

MELBOURNE, Australia, May 20, 2025 /PRNewswire/ -- Telix Pharmaceuticals Limited (ASX: TLX, NASDAQ: TLX, "Telix", "the Company") today announces a strong presence at the 55th Annual Scientific Meeting of the Australian and New Zealand Society of Nuclear Medicine (ANZSNM ASM 2025), to be held in Melbourne, Australia from 23–25 May 2025.

Telix will feature prominently in the scientific program with eight oral and three poster presentations highlighting the Company's late-stage and next-generation programs. Demonstrating its commitment to development and education in theranostics, Telix presentations include:

• ProstACT Global Phase 3 study of TLX591 (¹⁷⁷Lu-rosopatamab tetraxetan)^[1], Telix's first-in-class PSMA^[2] targeting radio antibody-drug conjugate (rADC) therapy candidate
• STARSTRUCK study of TLX250 (¹⁷⁷Lu-girentuximab) in combination with peposertib^[3] in patients with carbonic anhydrase IX (CAIX)-expressing solid tumors^[4], and a preclinical evaluation of ²²⁵Ac-girentuximab in combination with DNA damage response inhibition
• Zolar study of TLX300-CDx (⁸⁹Zr-olaratumab)^[5], a theranostic approach in soft tissue sarcoma
• ZIRCON-CP study of TLX250-CDx (Zircaix®^[6], ⁸⁹Zr-girentuximab), Telix's kidney cancer PET^[7] radiodiagnostic candidate in Chinese patients with indeterminate renal masses^[8]
• TLX250-CDx early access in Australia and Italy highlighting clinical utility in clear cell renal cell carcinoma (ccRCC)
• D2, a first-in-class, dual-chelator theranostic that could enable the use of imaging-therapy radiometal pairs of different elements^[9]
• Artificial intelligence (AI) enabled PSMA-PET/CT^[10] lesion delineation for prostate cancer.

Telix will also host a Breakfast Symposium showcasing real-world experience and impact on clinical decision making with TLX250-CDx, and clinical utility of PSMA-PET. Again we are pleased to support the Nurses' Workshop in collaboration with with the Prostate Cancer Foundation of Australia (PCFA), NeuroEndocrine Cancer Australia (NECA) and the Peter MacCallum Cancer Centre in Melbourne.

Telix will be at booth #28, where visitors can learn more about Telix's extensive late-stage theranostic pipeline in urologic oncology (prostate, kidney and bladder), neuro-oncology (glioma), musculoskeletal oncology (sarcoma) and hematology, our associated medical technologies and AI innovations, and opportunities for collaboration.

Details of ANZSNM ASM 2025 abstract presentations related to Telix programs are listed below and the full congress program can be accessed here.

All times AEST.

Saturday, 24 May 2025

Title: Preclinical evaluation of DNA damage response inhibitors and ²²⁵Ac-DOTA-girentuximab combination therapyPresenter: Zhipeng Cao, Olivia Newton-John Cancer Research InstituteTime: 11:00 AM – 12:30 PMSession: RPS Session including Shimadzu AwardLocation: Meeting Room 204

Title: D2 – Enabling a theranostic approach with ⁸⁹Zr/¹⁷⁷Lu in a single trifunctional ligand scaffoldPresenter: James Wood, The University of QueenslandTime: 11:00 AM – 12:30 PMLocation: Meeting Room 204Session: RPS Session including Shimadzu Award

Sunday, 25 May 2025

Title: A preliminary study on nnUNet-based PSMA-PET/CT lesion segmentation models: toward clinically informed trainingPresenter: David Han, Telix PharmaceuticalsTime: 11:00 AM – 12:30 PMLocation: Meeting Room 204Session: Scientific Session: Oncology 3

Title: ZOLAR, an open-label, Phase 1 study to assess safety, tolerability, dosimetry, pharmacokinetics, and imaging properties of ⁸⁹Zr-olaratumab (TLX300-CDx) in patients with soft tissue sarcomaPresenter: Corinne Letendre, Telix PharmaceuticalsTime: 11:00 AM – 12:30 PMLocation: Meeting Room 203Session: Scientific Session: Therapy / Phase 1 Trials

Title: ProstACT Global, a multinational, multicenter, prospective, randomized, controlled, open-label, Phase 3 study of ¹⁷⁷Lu -rosopatamab tetraxetan (TLX591) in combination with standard of care (SoC) versus SoC alone in patients with PSMA-positive metastatic castrate-resistant prostate cancer (mCRPC) after androgen receptor pathway inhibitor (ARPI) treatmentPresenter: Veronica Wong, Nepean HospitalTime: 11:00 AM – 12:30 PMLocation: Meeting Room 203Session: Scientific Session: Therapy / Phase 1 Trials

Title: STARSTRUCK, a Phase 1b dose escalation/expansion study of the combination of ¹⁷⁷Lu-girentuximab (TLX250) and peposertib in patients with carbonic anhydrase IX (CAIX)-expressing solid tumorsPresenter: Aviral Singh, GenesisCareTime: 11:00 AM – 12:30 PMLocation: Meeting Room 203Session: Scientific Session: Therapy / Phase 1 Trials

Title: ZIRCON-CP, a confirmatory, open-label, single-arm, multicenter study to evaluate the safety, tolerability, and diagnostic performance of ⁸⁹Zr-girentuximab (TLX250-CDx) to non-invasively detect ccRCC by PET/CT imaging in Chinese patients with indeterminate renal massesPresenter: Mary Jessel, Telix PharmaceuticalsTime: 2:00 PM - 3:30 PMLocation: Meeting Room 207Session: Scientific Session: Oncology Preclinical

Title: Preliminary investigation of radiation exposure of pathology staff from urine samples containing traces of ¹⁷⁷Lu-rosopatamab tetraxetan (TLX591)Presenter: Alessandra Malaroda, Nepean HospitalTime: 2:00 PM - 3:30 PMLocation: Meeting Room 204Session: Scientific Session: Oncology 4

Posters: Displayed throughout meeting

Title: Non-invasive detection of Nectin-4 and TROP2 in bladder cancer via ImmunoPETPresenter: Peter Chandler, Telix Pharmaceuticals

Title: Initial experience with ⁸⁹Zr-girentuximab (TLX250-CDx)Presenter: Alexis Dalagiorgos, Jones Radiology

Title: The emerging role of ⁸⁹Zr-girentuximab (TLX250-CDx) PET/CT in the management of ccRCC: Early experience in three patientsPresenter: Fabrizia Gelardi, Università Vita-Salute San Raffaele, Milan (Italy)

Breakfast Session and Nurses Workshop

Telix-Hosted Breakfast Location: Meeting Room 203Date and Time: Sunday, 25 May | 7:15 AM – 8:15 AMTopics and Presenters:

• Enhancing cancer care with precision radiopharmaceuticals: Expanded access for renal cancers – Sze Ting Lee, Austin Health
• Early diagnosis with PSMA-PET in prostate cancer – Michael Kitchener, Jones Radiology

Nurses Workshop Location: Meeting Room 205Date and Time: Saturday, 24 May | 12:30 PM – 1:30 PMTopics and Presenters:

• Interpreting liver function tests – Emma Boehm, Peter MacCallum Cancer Centre
• Gallium-68 PET, FDG PET and other imaging modalities – Aaron Wong, Peter MacCallum Cancer Centre
• Managing toxicities in theranostics – Gabby Cehic AM, SA Health
• Radiation safety during radiopharmaceutical therapy – Daniel Badger, SA Health

About Telix Pharmaceuticals Limited

Telix is a biopharmaceutical company focused on the development and commercialization of therapeutic and diagnostic radiopharmaceuticals and associated medical technologies. Telix is headquartered in Melbourne, Australia, with international operations in the United States, Brazil, Canada, Europe (Belgium and Switzerland), and Japan. Telix is developing a portfolio of clinical and commercial stage products that aims to address significant unmet medical needs in oncology and rare diseases. ARTMS, IsoTherapeutics, Lightpoint, Optimal Tracers and RLS are Telix Group companies. Telix is listed on the Australian Securities Exchange (ASX: TLX) and the Nasdaq Global Select Market (NASDAQ: TLX).

Illuccix® (kit for the preparation of gallium-68 (⁶⁸Ga) gozetotide injection), Telix's first generation PSMA-PET imaging agent, has been approved by the United States Food and Drug Administration (FDA)^[11], by the Australian Therapeutic Goods Administration (TGA)^[12], by Health Canada^[13], by the Brazilian Health Regulatory Agency (ANVISA)^[14], by the United Kingdom (UK) Medicines and Healthcare Products Regulatory Agency (MHRA)^[15], by the French National Agency for the Safety of Medicine and Health Products (ANSM)^[16] and in multiple countries within the European Economic Area (EEA)^[17] following a positive decentralized procedure (DCP) opinion by the German medical regulator, BfArM^[18]. Gozellix® (kit for the preparation of gallium-68 (⁶⁸Ga) gozetotide injection) has been approved by the U.S. FDA^[19].

TLX591, TLX250, TLX250-CDx and TLX300-CDx have not received a marketing authorization in any jurisdiction and are for investigational use only.

Visit www.telixpharma.com for further information about Telix, including details of the latest share price, ASX and SEC filings, investor and analyst presentations, news releases, event details and other publications that may be of interest. You can also follow Telix on LinkedIn, X and Facebook.

Telix Investor Relations

Ms. Kyahn WilliamsonTelix Pharmaceuticals LimitedSVP Investor Relations and Corporate CommunicationsEmail: kyahn.williamson@telixpharma.com

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