The first phase of Prime Minister Scott Morrison’s four-stage “pathway out of the COVID-19 pandemic”, announced on Friday, focuses on vaccinating as many Australians as possible, while halving the cap on international arrivals.
Morrison expects phase one, which we’re currently in, to be in place until 2022. But he said it’s hard to give a definitive answer on when we’ll get to phase two because vaccination targets have not yet been set. He’s waiting for the modelling.
Phase two of Morrison’s plan is a move back to the current levels of international arrivals, and a separate cap for vaccinated travellers. Phase three sees Australians able to travel abroad and no cap on returnees.
We are undertaking our own detailed modelling of border openings and while we’re yet to release our models, we can still arrive at fairly solid conclusions now. We’re basing these on the theory that Australia could substantially open its borders in the second quarter of 2022 with quarantine-free travel from many (but not all) countries.
The key trick, though, is to not think of vaccination as the only intervention. It is vaccination — together with three other measures: ongoing aggressive contact tracing, mask-wearing in high-risk settings and some physical distancing — that will make it safe to open.
Put another way, even when we immunise all Australians who want to be protected against COVID-19, we’re unlikely to achieve herd immunity through vaccination alone.
Modelling performed by the University of Sydney, the Burnett Institute and previously by us all point to the reality that opening the borders before about two-thirds of the population is vaccinated (in the absence of strong additional methods) could cause considerable illness and death.
So it seems unethical to substantially open the borders until everyone has had a fair opportunity to get vaccinated. All going well, this should occur sometime in the second quarter of 2022.
This would, however, be dependent on children also having the opportunity to be vaccinated. While other countries have started vaccinating children, Australia has yet to approve this use.
Vaccination alone won’t get us herd immunity
Some vaccination programs alone can achieve herd immunity, or resilience, meaning the virus won’t spread easily and exponentially, in the absence of masks, contact tracing and the other measures we have used during the pandemic.
But given the Delta variant means an average infected person infects five others without any other measures in place, and given vaccines are not perfect, Australia would need 90% of adults and children vaccinated to achieve herd immunity (through vaccination alone). This is unlikely.
There will be some waning in vaccine immunity over time, and new variants for which Pfizer and AstraZeneca are less effective. However, even with 100% of the population vaccinated, herd immunity may not be achieved by vaccination alone until booster vaccines become available.CDC/Unsplash
How did we get to 90%?
The Delta variant has an R0 (the number of people one infected person on average infects) of about 5.0 under pre-COVID-19 ways of living. This is twice that of the original Wuhan virus which had an R0 about 2.5.
For an R0 of 5.0, theoretically, 80% of the population have to be immune — not just vaccinated — for virus transmission not to take off.
But the actual vaccine coverage required is higher, as the vaccines aren’t 100% effective at stopping any infection. And even though a person has been vaccinated, it doesn’t mean they’re always immune from the virus, as the person may not develop a strong immune response.
Vaccination with two doses of Pfizer among adults aged 16-60 years old is likely about 80% successful at stopping any Delta infection. For those 60 or older, the effectiveness of AstraZeneca at reducing the risk of any infection is less: about 60% against the Delta virus.
Over half, 58%, of the population are aged 16-59, and 23% of the population are aged 60-plus. So for 80% vaccination coverage of adults, the estimated percentage of the population who are immune is 48% — well short of the 80% herd immunity threshold.
For those still at risk of getting infected after either Pfizer or AstraZeneca vaccination, they are 50% less likely to transmit it. So the 16% of the population who were vaccinated but can still get infected are half as likely to pass it on.
The remaining 36% of the population are fully susceptible (20% of adults, and all children).
Extending this maths, we need about 90% of everyone (children and adults) to be vaccinated to achieve herd immunity. This is unlikely to happen.
What’s our alternative?
Using both the above theory, and what we have seen so far in our modelling, we can outline scenarios going forward:
Authors: Tony Blakely, Professor of Epidemiology, Population Interventions Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne