Daily BulletinDaily Bulletin

The Conversation

  • Written by The Conversation
imagePreparation of monoclonal antibodies in the labLinda Bartlett/Wikimedia Commons

They are tiny magic bullets that are quietly shaping the lives of millions of patients around the world. Produced in the lab, invisible to the naked eye, relatively few people are aware of these molecules' existence or where they came from. Yet monoclonal antibodies are contained in six out of ten of the world’s bestselling drugs, helping to treat everything from cancer to heart disease to asthma.

Known as Mabs for short, these molecules are derived from the millions of antibodies the immune system continually makes to fight foreign invaders such as bacteria and viruses. The technique for producing them was first published 40 years ago. It was developed by César Milstein, an Argentinian émigré, and Georges Köhler, a German post-doctoral researcher. They were based at the UK Medical Research Council’s Laboratory of Molecular Biology in Cambridge.

Harnessing the power of the immune system

Milstein and Köhler wanted to investigate how the immune system can produce so many different types of antibodies, each capable of specifically targeting one of a near-infinite number of foreign substances that invade the body. This had puzzled scientists ever since the late 19th century, but an answer had proved elusive. Isolating and purifying single antibodies with known targets, out of the billions made by the body, was a challenge.

The two scientists finally solved this problem by immunising a mouse against a particular foreign substance and then fusing antibodies taken from its spleen with a cell associated with myeloma, a cancer that develops in the bone marrow. Their method created a hybrid cell that secreted Mabs. Such cells could be grown indefinitely, in the abdominal cavity of mice or in tissue culture, producing endless quantities of identical antibodies specific to a chosen target. Mabs can be tailored to combat a wide range of conditions.

When Milstein and Köhler first publicised their technique, relatively few people understood its significance. Editors of Nature missed its importance, asking the two scientists to cut short their article outlining the new technique; as did staff at the British National Research Development Corporation, who declined to patent the work after Milstein submitted it for consideration. Within a short period, however, the technique was being adopted by scientists around the world, and less than ten years later Milstein and Köhler were Nobel laureates.

A transformation in therapeutic medicine

In the years that have passed since 1975, Mab drugs have radically reshaped medicine and spawned a whole new industry. It is predicted that 70 Mab products will have reached the worldwide market by 2020, with combined sales of nearly $125bn (£81bn).

imageAn artist’s rendering of anti-cancer antibodies.ENERGY.GOV

Key to the success of Mab drugs are the dramatic changes they have brought to the treatment of cancer, helping in many cases to shift it away from being a terminal disease. Mabs can very specifically target cancer cells while avoiding healthy cells, and can also be used to harness the body’s own immune system to fight cancer. Overall, Mab drugs cause fewer debilitating side-effects than more conventional chemotherapy or radiotherapy. Mabs have also radically altered the treatment of inflammatory and autoimmune disorders like rheumatoid arthritis and multiple sclerosis, moving away from merely relieving symptoms to targeting and disrupting their cause.

Aside from cancer and autoimmune disorders, Mabs are being used to treat over 50 other major diseases. Applications include treatment for heart disease, allergic conditions such as asthma, and prevention of organ rejection after transplants. Mabs are also under investigation for the treatment of central nervous disorders such as Alzheimer’s disease, metabolic diseases like diabetes, and the prevention of migraines. More recently they were explored as a means to combat Ebola, the virus disease that ravaged West Africa in 2014.

Fast and accurate diagnosis

Mabs have enabled faster and more accurate clinical diagnostic testing, opening up the means to detect numerous diseases that were previously impossible to identify until their advanced stages. They have paved the way in personalised medicine, where patients are matched with the most suitable drug. Mabs are intrinsic components in over-the-counter pregnancy tests, are key to spotting a heart attack, and help to screen blood for infectious diseases like hepatitis B and AIDS. They are also used on a routine basis in hospitals to type blood and tissue, a process vital to ensuring safe blood transfusion and organ transplants.

imageMonoclonal antibodies can be used to rapidly diagnose disease and determine blood type.U.S. Navy/Jeremy L. Grisham

Mabs are also invaluable to many other aspects of everyday life. For example they are vital to agriculture, helping to identify viruses in animal livestock or plants, and to the food industry in the prevention of the spread of salmonella. In addition they are instrumental in the efforts to curb environmental pollution.

Quietly triumphant

Yet Mabs remain hidden from public view. This is partly because the history of the technology has often been overshadowed by the groundbreaking and controversial American development of genetic engineering in 1973, which revolutionised the manufacturing and production of natural products such as insulin, and inspired the foundation of Genentech, one of the world’s first biotechnology companies.

Looking back, the oversight is not surprising. Mabs did not transform medicine overnight or with any major fanfare, and the scientists who made the discovery did not seek fame. Instead, Mabs quietly slipped unobserved into everyday healthcare practice.

An Argentinian and a German came together in a British Laboratory and changed the face of medicine forever; their story deserves to be told.

Lara Marks has received funding from the UK Medical Research Council. She has research affiliations with Cambridge University and King's College London. She is author of 'The Lock and Key of Medicine: Monoclonal antibodies and the transformation of healthcare' (Yale University Press, 2015).

Authors: The Conversation

Read more http://theconversation.com/monoclonal-antibodies-the-invisible-allies-that-changed-the-face-of-medicine-45807

Why the coronavirus shouldn't stand in the way of the next wage increase


Seeing is believing: how media mythbusting can actually make false beliefs stronger


Scott Morrison's address to the National Press Club


The Conversation


$1.8 billion boost for local government

The Federal Liberal and Nationals Government will deliver a $1.8 billion boost for road and community projects through local governments across Australia.   The package of support will help lo...

Scott Morrison - avatar Scott Morrison

Scott Morrison press conference

PRIME MINISTER: This is a tough day for Australia, a very tough day. Almost 600,000 jobs have been lost, every one of them devastating for those Australians, for their families, for their commun...

Scott Morrison - avatar Scott Morrison


Local economic recovery plans will help towns and regions hit by bushfires get back on their feet as part of a new $650 million package of support from the Morrison Government.   As part of th...

Scott Morrison - avatar Scott Morrison

Business News

How have live chatbots turned beneficial for online businesses?

Every business these days have come up with their online models. While some people still rely on the customer service representatives to handle the queries for their company around the clock through...

Paresh Patil - avatar Paresh Patil

Which Internet Marketing techniques can boost my business?

Internet marketing can be easily defined as various internet techniques that can be used to promote a product or service to all those people who use the internet to visit various websites and social p...

Kamballa Johnson - avatar Kamballa Johnson

3 Top Tips to Hiring Long Distance Movers

Moving doesn’t need to be stressful at all. Find the right moving company to help with your relocation and the whole experience should be what you want out of the move in the first place – a new sta...

Ash Thomson - avatar Ash Thomson

News Company Media Core

Content & Technology Connecting Global Audiences

More Information - Less Opinion